Bleomycin A5 sclerotherapy for cervicofacial lymphatic malformations

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Transmucosal Bleomycin for Tongue Lymphatic Malformations

Purpose: Bleomycin is an antibiotic medication that inhibits the synthesis of DNA, RNA, and proteins and is now used in a variety of medical conditions including vascular anomalies. The aim of this study was to evaluate the clinical efficacy of transmucosal intralesional injection of bleomycin in the management of tongue lymphatic malformations. Method: A single institutional case series was pr...

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Bleomycin is an established antineoplastic drug, but recently some attempts were made to inject it locally as a sclerosing agent in cases of congenital lymphatic malformations. We present the outcome of this treatment modality tried on 10 paediatric cases of whom 9 had such malformation in the cervical region and one in the parotid region. Seven of these cases had congenital lymphatic malformat...

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Picibanil Therapy for Cervicofacial Lymphatic Malformation

We present the case of a 4-year-old boy who was born with a large cervicofacial lymphatic malformation. It was partially resected in the first year of life and treated with Picibanil/OK-432 injections at the age of three because of recurrence. Eight months later the boy developed a fulminant streptococcal toxic shock syndrome with cardiac arrest. After resuscitation, high dose intravenous antib...

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ژورنال

عنوان ژورنال: Journal of Vascular Surgery

سال: 2011

ISSN: 0741-5214

DOI: 10.1016/j.jvs.2010.07.019